周骁，博士，副教授，硕士研究生导师。
长期从事T淋巴细胞、NK细胞功能和外部环境如热量限制、微塑料等对T细胞的功能影响及分子机制研究。擅长药理学、免疫学研究，采用蛋白质组、转录组、代谢组等联合分析揭示T细胞功能调控，并以此为基础筛选标志物。近5年主持国家自然科学基金青年基金项目1项，省级项目2项，参与国家级和省部级课题4项。先后以第一作者/通讯作者发表JCRQ1区SCI论文10余篇。
Email：xiao_zhou@csu.edu.cn /xiaozhou.0906@foxmail.com
一、教育经历：
[1] 2005.9-2009.7
中国药科大学，工学学士
[2] 2009.9-2012.6
中国药科大学，理学硕士
[3] 2012.7-2017.9
Saarland University，博士（PhD）
二、科研项目：
[1]湖南省自然科学基金青年基金项目，2025JJ50494，T细胞耗竭特异性的染色质外环状DNA（eccTMBIM6）作为脓毒血症预后的预测标志物研究，2025/01-2027/12，5万元，主持；
[2]国家自然科学基金面上项目，82102472，“热量限制”调控细胞毒T细胞CRAC通道促进免疫杀伤作用的机制及其免疫学标志物研究，2022/01-2024/12，30万元，主持；
[3]国家自然科学基金重点项目，82130090，能量代谢调控在银屑病中的作用与机制研究，2022/01-2026/12，291万元，参与（第四）；
[4]湖南省自然科学基金青年基金项目，2020JJ5875，Hippo通路—钙释放激活钙离子通道crosstalk调控细胞毒性T淋巴细胞耗竭，2020/01-2022/12，5万元，主持
[5]中南大学湘雅三医院，双“PI”项目，202401-2025-12，5万元，主持。
三、研究方向：
[1]饮食（热量）限制与免疫调控及机制
[2]钙离子通道与免疫细胞应答和功能紊乱调控
[3]肿瘤疫苗及免疫细胞应答
[4]其他免疫系统、免疫细胞功能的调控作用及机制
四、代表性论文：
[1]Tian Z, Ding B, Guo Y, Zhou J, Jiang S, Lu J, Li N,Zhou X, Zhang W. Microplastics accumulated in breast cancer patients lead to mitophagy via ANXA2-mediated endocytosis and IL-17 signaling pathway.Environmental Pollution,2025, 364: 125321.
[2]Liu N,Zhou X, Lu S, Luo G, Wu Z, Zhang C, Li J, Zhang Y, Zhang L. Injectable Hydrogel Delivery System with Nintedanib and Chloroquine Triggers Apoptosis and Inhibits Protective Autophagy.ACS Applied Polymer Materials,2024, 6(12): 7148-7160.
[3]Gao G, Li X, Wu H, Huang L li, Lin Y xin, Huo Z, Xiang Z yuan,Zhou X. LncRNA SNHG6 Upregulates KPNA5 to Overcome Gemcitabine Resistance in Pancreatic Cancer via Sponging miR-944.Pharmaceuticals,2023, 16(2): 184.
[4]Xiao H, Feng X, Liu M, Gong H,Zhou X. SnoRNA and lncSNHG: Advances of nucleolar small RNA host gene transcripts in anti-tumor immunity.Frontiers in Immunology,2023, 14: 1143980.
[5]Wang J, Wang X, Zhang C,Zhou X. Microplastics induce immune suppression via S100A8 downregulation.Ecotoxicology and Environmental Safety,2022, 242: 113905.
[6]Zhou X, Chen X, Han L, Liu H. Mechanisms underlying immune-related adverse events during checkpoint immunotherapy.Clinical Science (London, England: 1979),2022, 136(10): 771-785.
[7]Liu P, Gao G,Zhou X, Zhang X, Cai Q, Xiang Z, Shen X, Wu X. Circular RNA profiles of osteoarthritic synovium.Molecular Omics,2022, 18(5): 439-448.
[8]Zhou X, Friedmann K S, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes C S, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer B A, Lis A, Qu B, Kummerow C, Schwarz E C, Hoth M. A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.The Journal of Physiology,2018, 594(14): 2681-2698.
[9]Schoppmeyer R, Zhao R, Cheng H, Hamed M, Liu C,Zhou X, Schwarz E C, Zhou Y, Knörck A, Schwär G, Ji S, Liu L, Long J, Helms V, Hoth M, Yu X, Qu B. Human profilin 1 is a negative regulator of CTL mediated cell-killing and migration.European Journal of Immunology,2017, 47(9): 1562-1572.
[10]Zhou X, Zhao R, Schwarz K, Mangeat M, Schwarz E C, Hamed M, Bogeski I, Helms V, Rieger H, Qu B. Bystander cells enhance NK cytotoxic efficiency by reducing search time.Scientific Reports,2017, 7(13): 44357-44368.
[11]Law J K Y, Susloparova A, Vu X T,Zhou X, Hempel F, Qu B, Hoth M, Ingebrandt S. Human T cells monitored by impedance spectrometry using field-effect transistor arrays: a novel tool for single-cell adhesion and migration studies.Biosensors & Bioelectronics,2015, 67: 170-176.
[12]Fang Y, Yan J, Li C,Zhou X, Yao L, Pang T, Yan M, Zhang L, Mao L, Liao H. The Nogo/Nogo Receptor (NgR) Signal Is Involved in Neuroinflammation through the Regulation of Microglial Inflammatory Activation.The Journal of Biological Chemistry,2015, 290(48): 28901-28914.
[13]Yan J,Zhou X, Guo J J, Mao L, Wang Y J, Sun J, Sun L X, Zhang L Y, Zhou X F, Liao H. Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro.Journal of Neurochemistry,2012, 120(5): 721-731.